| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Baker Mayfield |
1. Baker Mayfield, QB | TB | W 34-20 at GB | 22 | 28 | 381 | 4 | 0 | 5 | 1 | 158.3 |
| 2. Joe Flacco, QB | CLE | W 20-17 vs. CHI | 28 | 44 | 374 | 2 | 3 | 4 | 0 | 77.3 | |
| 3. Jake Browning, QB | CIN | W 27-24 vs. MIN | 29 | 42 | 324 | 2 | 1 | 4 | 0 | 97.7 | |
| 4. Patrick Mahomes, QB | KC | W 27-17 at NE | 27 | 37 | 305 | 2 | 2 | 3 | 0 | 92.7 | |
| 5. Nick Mullens, QB | MIN | L 27-24 at CIN | 26 | 33 | 303 | 2 | 2 | 3 | 0 | 99.9 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
James Cook |
1. James Cook, RB | BUF | W 31-10 vs. DAL | 25 | 179 | 7.2 | 1 | 24 | 0 | |
| 2. Kyren Williams, RB | LAR | W 28-20 vs. WSH | 27 | 152 | 5.6 | 1 | 27 | 2 | ||
| 3. Ty Chandler, RB | MIN | L 27-24 at CIN | 23 | 132 | 5.7 | 1 | 30 | 0 | ||
| 4. Devin Singletary, RB | HOU | W 19-16 at TEN | 26 | 121 | 4.7 | 0 | 19 | 0 | ||
| 5. Christian McCaffrey, RB | SF | W 45-29 at ARI | 18 | 115 | 6.4 | 1 | 26 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Chris Godwin |
1. Chris Godwin, WR | TB | W 34-20 at GB | 10 | 155 | 15.5 | 0 | 25 | 0 | |
| 2. Jaylen Waddle, WR | MIA | W 30-0 vs. NYJ | 8 | 142 | 17.8 | 1 | 60 | 0 | ||
| 3. Terry McLaurin, WR | WSH | L 28-20 at LAR | 6 | 141 | 23.5 | 1 | 48 | 0 | ||
| 4. Joshua Palmer, WR | LAC | L 63-21 at LV | 4 | 113 | 28.3 | 1 | 79 | 0 | ||
| 5. Amon-Ra St. Brown, WR | DET | W 42-17 vs. DEN | 7 | 112 | 16.0 | 1 | 29 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Khaleke Hudson |
1. Khaleke Hudson, LB | WSH | L 28-20 at LAR | 8 | 5 | 13 | 0.0 | 0 | 0 | 0 |
| 2. Azeez Al-Shaair, LB | TEN | L 19-16 vs. HOU | 7 | 6 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Cody Barton, LB | WSH | L 28-20 at LAR | 5 | 8 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Eric Kendricks, LB | LAC | L 63-21 at LV | 9 | 3 | 12 | 1.0 | 0 | 0 | 0 | |
| 5. Alex Anzalone, LB | DET | W 42-17 vs. DEN | 7 | 5 | 12 | 0.0 | 0 | 0 | 0 | |